TiO₂ 나노튜브를 형성한 Ti-6Al-4V 합금의 석회화 순환처리가 생체활성도에 미치는 영향
Effect of Cyclic Pre-calcification on the Bioactivity of Ti-6Al-4V Alloy Modified by Nonotubular TiO₂ Layer
송재주, 한아름, 정세진, 석홍병, 변선미, 임청하,
소속 상세정보
송재주 ( Song Jae-Joo ) - 청암대학교 치위생과
한아름 ( Han A-Lum ) - 원광대학교 의과대학 가정의학교실
정세진 ( Jung Se-Jin ) - 전북대학교 대학원 치의학과
석홍병 ( Shi Hong-Bing ) - 전북대학교 대학원 치의학과
변선미 ( Byeon Seon-Mi ) - 전북대학교 대학원 치의학과
임청하 ( Lim Chung-Ha ) - 전북대학교 대학원 바이오나노시스템공학과
KMID : 1035320160430030223
Abstract
The purpose of this study was to evaluate the effect of calcium phosphate treatment on the bioactivity of Ti-6Al-4V alloy modified by anodic oxidation, pre-calcification treatment, and heat treatment. Anodic oxidation were performed to increase specific surface area and form nanotubular TiO₂ layer (AH). After that, pre-calcification treatment was carried out in NaH2PO4 solution and Ca(OH)₂ saturated solution for 10 cycles (APH 10) and 30 cycles (APH 30) to induce the precipitation of calcium phosphates on surface. Additionally, the specimens were heat treated for structural stability and elimination of remaining impurities. The nanotubes were shown densely on the AH group. APH 10 and 30 groups showed the precipitated calcium phosphate on the nanotubular TiO₂ layer, but the APH 30 group showed more precipitation of calcium phosphate. Additionally, APH 10 and 30 groups showed the precipitation of HAp after immersion in SBF for 3 days. Compared to the untreated group, the surface treatment groups (AH, APH 10, and APH 30) showed a significant increase in surface roughness (p < 0.05), and the APH 30 group showed the highest surface roughness. Contact angle was decreased significantly in the surface treated groups compared to the untreated group (p < 0.05), and wettability was highest in APH 30 group. Consequently, we found out that APH 30 group greatly improved bioactivity by formation of nanotubular TiO₂ layer and HAp precipitation.
키워드
Bioactivity; Nanotubular TiO₂ layer; Pre-calcification (10; 30 cylces); Ti-6Al-4V alloy Implant
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